20 credits at level HE6
The aim of this modules is to investigate the impact of molecular evolution over time in selected species / groups.
Differences at the Molecular Level. Examples of biochemical and immunological differences. Variation of nuclear material. Examples of gene mutations (such as those affecting metabolic pathways) and chromosomal aberrations. Spontaneous and induced mutations, photo reactivation
Methods of Detection. Methods used to detect evolutionary difference at the molecular level including karyotyping, electrophoresis, microcomplement fixation, DNA hybridization and amino acid sequencing (The techniques of DNA isolation and the polymerase chain reaction covered here).
Evolutionary Pathways. Evolution of specific proteins, (from a range of species) differing evolutionary rates, concept of proteins as molecular clocks. Evolution of biochemical pathways (e.g. in the Monera). Origin of organelles, endosymbiotic hypothesis. Reconstruction of phylogeny, parsimony analysis. Adaptation, specialisation, extinction. Embryological development of the eye. Polymorphism in populations, Neis coefficient. A study of the molluscan eye. Evolution of the Hominoidea from a molecular perspective, Mitochondrial Eve. DNA fingerprinting.
Classification theories, including cladistics, phenetics, orthodox classification. Drawing of dendrograms, cladograms.
Numerical Taxonomy. An in-depth study of how a selection of organisms (e.g. bacteria, fishes) can be classified by biochemical differences using numerical taxonomy
Practicals include: Standard microbiological techniques, bacterial mutagenesis using UV light: Different separation techniques (e.g. paper chromatography of Drosophila mutants) and electrophoresis of muscle proteins (intraspecific variation). Isolation, duplication (PCR) and quantitative measurement of DNA.
Learning and Teaching Methods
Lectures, laboratory practicals and tutorials. Normally one hour lecture followed by a 2 hour related practical. Occasionally substituted by tutorial
Class contact (13 weeks @ 3 hours) = 39 hours
Private study = 120 hours
Assessment 3 hour exam = 3 hours
2 coursework @ 19 hours = 38 hours
(1 essay + 1 practical folder)
Total: = 200 hours
when you have successfully completed this module you will:
to demonstrate that you have achieved the learning outcome you will:
|1.||Have a sophisticated grasp of up-to-date subject knowledge, theoretical concepts and specialist analytical techniques relating to molecular evolution.||
1a identify a range of intra- and inter specific differences at the molecular level;
1b explain how proteins and nucleic acids can be used as molecular clocks and be used to determine evolutionary relationships;
1c give a detailed explanation of different taxonomic methods
1d explain how specialist biochemical techniques are a useful tool in evolutionary biology.
|2.||Be able to express yourself clearly and confidently in writing which is critical and evaluative;||produce a clear, concise and reasoned essay and examination answer with substantial critical and analytical content;|
|3.||Be able to analyse and evaluate scientific data/information and arrive at reasoned conclusions.||produce a clear, concise , scientific folder of experimental work with critical evaluation of data and discussion of importance/significance of findings;|
|4.||Be able to use a wide range of reference sources.||appropriately select, evaluate and incorporate a substantial amount of up-to-date reference material into their work.|
|5.||5a Be able to use specialist laboratory equipment correctly;
5b Be able to handle all chemicals (hazardous/non hazardous) safely
|competently and efficiently use specialist laboratory equipment/chemicals to obtain data for analysis.|
Your achievement of the learning outcomes for this module will be tested as follows:
Before taking this module you must have successfully completed the following:
No restrictions apply.
Campbell, N.A. (2001) Biology (6th Ed.) Benjamin Cummings
Cook, L.M. & Callow, R.S. (1998) Genetic and Evolutionary Diversity (2nd Ed.) Chapman & Hall
Gillespie, J.H. (1994) The Causes of Molecular Evolution. Oxford University Press
Kirby, L.T. (1990) DNA Fingerprinting. Stockton Press.
Panchen, A.L. (1992) Classification, Evolution and the Nature of Biology. Cambridge University Press
Reed, R., et al. (2003) Practical Skills in Biomolecular Sciences (2nd Ed.) Pearson/Prentice Hall
Ridley, M. (2004) Evolution (3rd Ed.) Blackwell Scientific Publications
Skelton, P & Gilmour, I.. (Editors) (1993) Evolution. Addison-Wesley
Snustad, P.D., Simmons, M.J. & Jenkins, J.B. (2003) Principles of Genetics (3rd Ed). John Wiley & Sons
Strachan, T. (1992) The Human Genome. BIOS Scientific Publishers (out of print, but available in library)
Strickberger, M.W. (1990) Genetics (3rd Ed.) Maxwell Macmillan (out of print, but available in the library)
|Host Subject Group:||Psychology and Life Sciences|
|User Name||Date Accessed||Action|